Profile

Research Interests

• Aero-antigens sensitized canonical allergic asthma revealed with Th2 immune response, whereas, respiratory viruses (like H5N1, RV-1B, RSVs, HSV) induced exacerbation resulting in a typical Th2/Th1/Th17/Th1-Th2/Th1-Th17/Th2-Th17 or even Th9 and Paucigranulocytic responses. Besides, influenza or RVs induced exacerbated asthma (having either Th1 or Th17 signatures) showing very poor or ineffective response to either corticosteroids or other ongoing therapies. Using different infectious murine models, I am interested to focus on mechanistic pathways, and innate-adoptive signaling of Th1, and Th17 phenomena to corroborate the exact characterization of cellular trafficking, cytokine streaming, activation of transcription factors, chemokine and chemokine receptors, tight junctions and adhesion molecules, along with subsequent roles of different inflammasomes, those will provide an effective way to justify new therapeutics. Moreover, post-influenza (H1N1-PR8) methicillin-resistant Staphylococcus aureus (MRSA) co-infection pneumonia models are addressing a new window to study the mechanistic pathways and immunological responses in pediatric patients.
• A bunch of epidemiological data corroborated the pediatric allergic asthma development through the placental transmission from their asthmatic mothers. In both vertical and horizontal cases, there are significant complex roles of stem cells, innate lymphoid cells (ILCs), and inflammasomes (NLRP3, AIM2, etc.) in the augmentation of airway remodeling. So undoubtedly, if we can make the transition of neutrophilic state (Th1/Th17) towards eosinophilic (Th2) response, then that Th2 pathogenesis could be controlled by applying corticosteroids or standard immunotherapeutics. Secondly, we have yet to define the mechanistic roles of stem cells in the progression and vertical transmission of maternal allergic asthma to neonates. Using the mice model, I have practical experience characterizing and sorting different stem cells from the placenta, AGM (Aorta-gonad-mesonephros), yolk-sac, embryos head, and neonatal bone marrow. Now, I am interested in identifying the possible mechanistic pathways through which hematopoietic stem cells (HSCs) induce vertical allergic asthma reactions (from mothers to kids).
• Very recently, I have designed the work on food safety, stressing a significant human health concern worldwide, particularly in developing countries. I am currently working on characterizing different antimicrobial-resistant (AMR) genes usually transmitted from milk and animals to humans. Antimicrobial resistance is one of the world’s most pressing public health problems due to its rapidly increasing nature and ultimate hazards to food safety and security.